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Genome assembly and characterization of a complex zfBED-NLR gene-containing disease resistance locus in Carolina Gold Select rice with Nanopore sequencing

https://doi.org/10.1371/journal.pgen.1008571

Read, Andrew C. ; Moscou, Matthew J. ; Zimin, Aleksey V. ; Pertea, Geo ; Meyer, Rachel S. ; Purugganan, Michael D. ; Leach, Jan E. ; Triplett, Lindsay R. ; Salzberg, Steven L. ; Bogdanove, Adam J. ( January 2020 , PLOS Genetics)
Coaker, Gitta (Ed.)
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Stem rust resistance in wheat is suppressed by a subunit of the mediator complex

https://doi.org/10.1038/s41467-020-14937-2

Hiebert, Colin W. ; Moscou, Matthew J. ; Hewitt, Tim ; Steuernagel, Burkhard ; Hernández-Pinzón, Inma ; Green, Phon ; Pujol, Vincent ; Zhang, Peng ; Rouse, Matthew N. ; Jin, Yue ; et al ( February 2020 , Nature Communications)

Abstract
Stem rust is an important disease of wheat that can be controlled using resistance genes. The geneSuSr-D1identified in cultivar ‘Canthatch’ suppresses stem rust resistance.SuSr-D1mutants are resistant to several races of stem rust that are virulent on wild-type plants. Here we identifySuSr-D1by sequencing flow-sorted chromosomes, mutagenesis, and map-based cloning. The gene encodes Med15, a subunit of the Mediator Complex, a conserved protein complex in eukaryotes that regulates expression of protein-coding genes. Nonsense mutations in Med15b.D result in expression of stem rust resistance. Time-course RNAseq analysis show a significant reduction or complete loss of differential gene expression at 24 h post inoculation inmed15b.Dmutants, suggesting that transcriptional reprogramming at this time point is not required for immunity to stem rust. Suppression is a common phenomenon and this study provides novel insight into suppression of rust resistance in wheat.

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